There are two ways.
•        Upgrade. You can increase a card's stats by upgrading it. All you need to do is collect the necessary items shown on the card's upgrade info sheet, spend a few Cartman Coins, and BOOM - upgrade complete. The number of upgrades per card is strictly limited according to the regulations of the Canadian Bureau of Mobile Games. But when no more upgrades are available, fear not. Because there is also level up.
•        Level up. When cards cannot be upgraded anymore, they can be leveled up. Leveling up a card does a great deal of improvement to the card stats at the same time (Health and Attack, and maybe something else!). More importantly, it increases the amount of upgrades the card can have. Leveling up a card couldn't be easier: Just collect enough copies of the card, drop a few Cartman coins, and SHAZAM - card leveled up. All cards start at level 1 and can be upgraded a whopping six times.